The last team to have two or fewer players reach the 100 game mark was the 1906 Saint Louis Cardinals. Pug Bennet, a 32 year old rookie, played in 153 games for that team as it finished seventh with 98 losses. That was the only team to do it in the 20th century.
So when Ron Gardenhire says he has never seen anything like this in terms of injuries, neither has anyone else. Its not really surprising the Twins have struggled with only the 6th and 8th batter in opening day lineup playing on a regular basis.